Researchers at the University of Kentucky have found that fasting can help reduce the impact of a moderate traumatic brain injury.
Fasting within the first 24 hours of the injury reduces the levels of several biomarkers of mitochondrial dysfunction and cellular damage that cause a breakdown of brain tissue, according to the research team, led by Patrick Sullivan of the UK Spinal Cord and Brain Injury Research Center (SCoBIRC).
The researchers found significant recovery of tissue sparing and cognitive function in test subjects who fasted for 24 hours following a moderate brain injury.
Laurie Davis, a graduate student and lead author on the manuscript, reported that researchers looked at the effects of low blood glucose induced by insulin administration, and found this approach was not neuroprotective and in fact increased mortality in some cases.
The researchers then administered ketones and found significant improvements in tissue sparing. This led them to believe ketones generated during fasting provided a neuroprotective benefit.
The team reports its findings in the Journal of Neuroscience Research.
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Source: University of Kentucky
Fasting within the first 24 hours of the injury reduces the levels of several biomarkers of mitochondrial dysfunction and cellular damage that cause a breakdown of brain tissue, according to the research team, led by Patrick Sullivan of the UK Spinal Cord and Brain Injury Research Center (SCoBIRC).
The researchers found significant recovery of tissue sparing and cognitive function in test subjects who fasted for 24 hours following a moderate brain injury.
Laurie Davis, a graduate student and lead author on the manuscript, reported that researchers looked at the effects of low blood glucose induced by insulin administration, and found this approach was not neuroprotective and in fact increased mortality in some cases.
The researchers then administered ketones and found significant improvements in tissue sparing. This led them to believe ketones generated during fasting provided a neuroprotective benefit.
The team reports its findings in the Journal of Neuroscience Research.
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Source: University of Kentucky
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